Andrew Spence

Molecular Genetics


MaRS West Tower
661 University Avenue, Room 1501, Toronto, Ontario Canada M5G 1M1
Research Interests
C. elegans, Developmental biology, Epigenetics and epigenomics, Gene regulation and expression, Non-coding DNA and RNA, Signalling

We are interested in the genetic control of development, focussing on the genes that determine sex in the nematode Caenorhabditis elegans. We described a novel form of epigenetic regulation that depends upon maternally contributed RNA to license gene expression in the germline of the next generation, and we are using genetic and genomic approaches to understand its mechanism.

Courses taught

  • MGY340 Molecular Genetics
  • MGY460 Genetic Analysis of Development