Faculty Candidate Seminar: Benjamin Martin, Harvard Medical School
Candidate for Assistant Professor, Molecular Biology & Genetics
Benjamin Martin, PhD Postdoctoral fellow, Harvard Medical School
Date: Wednesday, May 15, 2024, 11:00 a.m.
Location: Room 3278, Medical Sciences Building
Functional compensation in chromatin remodeling and transcription regulation
Mammalian SWI/SNF chromatin remodeling complexes play critical roles in generating accessible DNA at gene promoters and enhancers. Here, I will present our recent results leveraging a fast-acting inhibitor of SWI/SNF remodeling to elucidate the direct targets and effects of SWI/SNF. In this work, we uncovered a compensatory role for the EP400/TIP60 remodeler in reestablishing accessibility at most promoters during prolonged loss of SWI/SNF. Additionally, we observed synthetic lethality between EP400 and SWI/SNF in cancer cell lines and human cancer patient data. I will conclude the seminar by outlining plans for my independent research group.