Feb 12, 2024  |  3:00pm - 4:00pm
Molecular Genetics Seminar Series

Winter Seminar Series - Dr. Isaac Chui, Harvard Medical School

Molecular Genetics Colloquium MMG1003H: Winter 2024 Seminar Series

Dr. Isaac Chui, Harvard Medical School
Title: Neuronal regulation of barrier immunity and host defense

Date: Monday, February 12th, 2024

Time: 3:00 PM - 4:00 PM EST 

Location: MSB 3153

Host: Dr. Julie Lefebvre

Talk Abstract:
Neuroimmune interactions play a critical role in regulating homeostasis and host defense. Barrier tissue sites are densely innervated by sensory neurons that mediate pain and itch. We and others have found that these neurons directly sense microbial pathogens and their mediators including toxins and enzymes. They then release neuropeptides and other mediators that signal to immune cells to regulate their function. Microbes also in some instances hijack these neuroimmune interactions for their advantage. Therefore, understanding how neurons interact with microbes and immune cells can lead to novel understanding of host defense and barrier immunity.

Research Topic: Immune-neuron Interactions; Mouse Models.