Dr. Gingras focuses on the study of signalling pathways and cellular organization using systematic approaches.
She is an expert in mass spectrometry-based proteomics, a technology that enables the identification and quantification of proteins from biological samples. Her lab specializes in developing tools to better understand how proteins associate with one another to perform their functions. She has developed experimental and bioinformatics approaches to confidently identify, quantify, and visualize interaction and proximity partners for proteins of interest. She continues to be a strong advocate for data transparency and data sharing, and for the development of user-friendly bioinformatics tools. Using the approaches that she developed, her group has identified new protein complexes and signalling components that provide a better understanding of perturbations associated with cancer and rare diseases. She has also implemented innovative strategies for the interpretation proximity-dependent biotinylation (BioID) data that can reveal the organization of membraneless organelles inside living cells, and more recently, of all organelles in the cell (humancellmap.org). She has multiple active scientific collaborations, notably with other members of the Molecular Genetics departments.
The Gingras lab is located at the Lunenfeld-Tanenbaum Research Institute, Sinai Health where Dr. Gingras is a Senior Investigator. She holds Canada Research Chair in Functional Proteomics and the Lea Reichmann Chair in Cancer Proteomics and a Full Professor in the Department of Molecular Genetics at the University of Toronto. She also serves as deputy editor of Molecular and Cellular Proteomics and as a co-director of the Network Biology Collaborative Centre (nbcc.lunenfeld.ca). Dr. Gingras has published >250 research articles and review articles that have already been cited >45,000 times.
- MMG 1001 - Proteins and Proteomics module
- Canada Research Chair (Tier 1) in Functional proteomics
- Fellow of the Royal Society of Canada, an elected member of the European Molecular Biology Organization (EMBO)
- CSMB Jeanne Manery Fisher Memorial Lecture (2019)
- HUPO Discovery Award (2019)
- CNPN Tony Pawson Award (2020)
- Lunenfeld-Tanenbaum Research Institute