Peter Gilgan Centre for Research and Learning
686 Bay Street, 14-9714, Toronto, Ontario Canada M5G 0A4
Behaviour and mental illness, Bioinformatics and computational biology, Cancer, Chromosome biology, Disease models, Epigenetics and epigenomics, Neurodegeneration and neurodevelopment, Mouse models, Neuroscience, Imaging and microscopy, Protein-protein, DNA-protein, and RNA-protein interactions, Rare diseases, Structural biology
- Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
- Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
- Focus on DNA repair, replication & epigenetics.
- Identify therapeutic targets and preclinical therapeutic drugs.