University Professor

Jack Greenblatt

Molecular Genetics


Terrence Donnelly Centre for Cellular & Biomedical Research
160 College Street, Room 906, Toronto, Ontario Canada M5S 3E1
Research Interests
Cancer, Chemical biology, Chromosome biology, CRISPR-Cas9 and genome engineering, Developmental biology, Disease models, Drug discovery, design, development and screening, Neurodegeneration and neurodevelopment, Neuroscience, Rare diseases, Stem cell biology

Our current major aims are to characterize RNA-binding by the >700 human C2H2 zinc finger transcription factors (C2H2-ZFPs) and explore their roles, together with those of their interacting proteins and other RNA-binding proteins, in genome organization and chromosome conformation, transcription by RNA polymerase II, mRNA modification, mRNA splicing, transcription termination, mRNA alternative 3'-end formation and polyadenylation, mRNA export to the cytoplasm, mRNA stability, and mRNA translation. In certain cases, we also investigate the involvement of these C2H2-ZFPs and the processes they regulate in various human diseases, especially cancer.

Courses taught

  • MGY420H1: Regulation of gene expression


  • Fellow of the Royal Society of Canada
  • Fellow of the American Academy of Microbiology
  • Medical Research Council of Canada Distinguished Scientist Award
  • Canadian National Proteomics Network Distinguished Researcher Award


  • Donnelly Centre