Our current major aims are to characterize RNA-binding by the >700 human C2H2 zinc finger transcription factors (C2H2-ZFPs) and explore their roles, together with those of their interacting proteins and other RNA-binding proteins, in genome organization and chromosome conformation, transcription by RNA polymerase II, mRNA modification, mRNA splicing, transcription termination, mRNA alternative 3'-end formation and polyadenylation, mRNA export to the cytoplasm, mRNA stability, and mRNA translation. In certain cases, we also investigate the involvement of these C2H2-ZFPs and the processes they regulate in various human diseases, especially cancer.
- MGY420H1: Regulation of gene expression
- Fellow of the Royal Society of Canada
- Fellow of the American Academy of Microbiology
- Medical Research Council of Canada Distinguished Scientist Award
- Canadian National Proteomics Network Distinguished Researcher Award
- Donnelly Centre