Our central objective is to gain mechanistic insight into the regulatory functions of the non-coding genome. In an interdisciplinary systems biology approach covering the fields of genome & RNA biology, live-cell imaging, biochemistry, and computational biology, we address 1) how chromosomal territories are organized, 2) how inter-chromosomal contacts facilitate gene regulation and genome organization, and 3) how yet uncharacterized long non-coding RNA genes function to better understand biology and etiology of disease.
- Functional Genomics (MGY428)
- Foundational Genetics Approaches II Colloquium (MGY1002H)
- Future Directions in Medical Genomics (MMG3006Y)
- Maud Menten New Principal Investigator Prizes in Genetics
- Canada Research Chair Tier 2 in Non-coding Disease Mechanisms
- Walter-Siegenthaler Award, 1st Silver Medal, Bayer AG
- Hospital for Sick Children