New research connects tobacco smoking, APOBEC activity, and nonsense mutations in cancer genomes
MoGen in the News
MoGen scientists publish their work in Science Advances
By
MoGen Communications
MoGen graduate Nina Adler, under Jüri Reimand's lab and in collaboration with Dr. Daniel Schramek, published their research findings in Science Advances. This study establishes a link between tobacco smoking, APOBEC activity, and nonsense mutations in cancer genomes. Through a systematic analysis of thousands of cancer genomes, their findings provide a deeper understanding of the DNA changes driving cancer's growth.
Researchers from the University of Toronto's Department of Molecular Genetics, led by Dr. Xi Huang and Dr. Weifan Dong, have developed a groundbreaking designer peptide therapy targeting glioblastoma (GBM). Their innovative approach disrupts a tumour-specific potassium channel complex, offering promising advancements in GBM treatment.
The team applied machine learning, a type of artificial intelligence that recognizes patterns in vast amounts of data, to gene expression data obtained from individual cells.