Terrence Donnelly Centre for Cellular & Biomedical Research
160 College Street, Room 1212, Toronto, Ontario Canada M5S 3E1
C. elegans, Drug discovery, design, development and screening, Microbiome, Metabolism
We use the simple nematode worm C.elegans as a model for the parasitic nematodes that infect over a billion humans. Specifically, we have uncovered the unusual metabolism they use to survive in the very low oxygen conditions that they encounter in the human gut and use both in vivo screens and in silico modelling to identify drugs that block this unique metabolism. Finally, we are exploring how the gut microbiome alters worm metabolism leading to new therapies.
- MGY428 (undergrad)
- Experimental Approaches in Functional Genomics (grad with Prof. Boone)
- Donnelly Centre