Assistant Professor

Brett Trost

Department of Molecular Genetics

PhD

Publications

Location

SickKids - Peter Gilgan Centre for Research and Learning

Address

686 Bay Street, M5G 0A4, 21.9709, Toronto, Ontario Canada M5G 0A4

Research Interests

Molecular Medicine & Human Genetics, Bioinformatics and computational biology, Behaviour and mental illness, Genome analysis and sequencing, Neurodegeneration and neurodevelopment, Non-coding DNA and RNA, Proteomics and proteins, Protein-protein, DNA-protein, and RNA-protein interactions

Dr. Trost's research program is dedicated to the creation and application of novel computational biology methods for detecting and interpreting genetic variation, especially in the context of neurodevelopmental and mental health conditions. His main current interest is in developing new ways to predict the pathogenicity of missense variants, such as by inferring their effects on protein-protein interactions and post-translational modifications.

Dr. Trost’s long-term aim is to leverage multi-omic data (e.g., transcriptomics, proteomics, metabolomics, and epigenetics) in combination with machine-learning approaches to better understand disease-associated genetic variation.

Awards

• 2022: Richard Todd Award, International Society of Psychiatric Genetics

• 2019–2020: Research Scholar Award, Canadian Open Neuroscience Platform

• 2018: Invited Participant, 68th Lindau Nobel Laureate Meeting

• 2017–2019: Banting Post-Doctoral Fellowship, Canadian Institutes of Health Research

• 2017–2019: Lap-Chee Tsui Fellowship for Research Excellence, The Hospital for Sick Children

• 2015: Governor General’s Academic Gold Medal, Government of Canada

• 2009–2012: Vanier Canada Graduate Scholarship, Natural Sciences and Engineering Research Council of Canada

Brett Trost

PhD

brett.trost@sickkids.ca

416-813-7654 - ext: 309027‬

Publications