Associate Professor

Evgueni (Zhenya) Ivakine

SickKids - Peter Gilgan Centre for Research and Learning
686 Bay Street, M5G 0A4, Toronto, Ontario Canada M5G 0A4
Research Interests
Genetic Models of Disease & Development, Molecular Medicine & Human Genetics, Functional Genomics & Proteomics. , Cancer, CRISPR-Cas9 and genome engineering, Disease models, Functional genomics and systems biology, Genome analysis and sequencing, Mouse models, Neurodegeneration and neurodevelopment, Rare diseases, Technology development

Dr. Ivakine seeks to understand disease pathogenesis and to develop next-generation genetic medicines for the treatment of rare inherited disorders.

His research includes:

  • Developing a powerful technique called saturation prime editing to predict disease risk at a single nucleotide resolution.
  • Generating cellular and animal models of disease to understand disease pathogenesis.
  • Developing and testing treatments for genetic diseases, particularly neurodevelopmental and neurodegenerative conditions like Niemann-Pick disease type C, Tay-Sachs disease, and Frontotemporal Dementia.
  • Utilizing genome engineering tools such as CRISPR-Cas9, prime editing, base editing, and CRISPR activation to study mutations that lead to genetic diseases and explore new ways of treating diseases at the DNA level.


  • MMG3006Y: Genetic Models of Disease & Development
  • MGY250: Molecular Medicine & Human Genetics
  • Functional Genomics & Proteomics