Miguel Ramalho-Santos

Molecular Genetics

PhD, MSc

Lunenfeld-Tanenbaum Research Institute
25 Orde Street, 6-1016-2, Toronto, Ontario Canada M5T 3H7
Research Interests
Chromosome biology, CRISPR-Cas9 and genome engineering, Developmental biology, Epigenetics and epigenomics, Gene regulation and expression, Mouse models, Non-coding DNA and RNA, Regenerative medicine and tissue engineering, Translation and post-transcriptional regulation

With each generation, the precise spatio-temporal unfolding of embryonic development requires a tight orchestration of dynamic changes in chromatin states and corresponding transcriptional programs. While development is often approached as simply hardwired in the genome, there is a growing appreciation that the environment provides key inputs into the bookmarking and activation of the genome during ontogeny, but such inputs remain very poorly understood at the mechanistic level. Our lab is interested in understanding the genome-environment interactions that shape mammalian development and reproduction. Of particular interest are pluripotent cells that exist in the mammalian embryo and give rise to all cell types of the body. Recent work from our lab highlights that such foundational aspects as genome organization and gene transcription are regulated in novel ways in pluripotent cells of mammalian embryo, and that environmental perturbations sensed by these cells may lead to long-term consequences.


  • MMG1017 Student Seminars (Co-instructor)


  • 2018 - Canada 150 Chair in Developmental Epigenetics, Federal Government of Canada
  • 2016 - Royan International Research Award in Reproductive Genetics, Royan Institute, Tehran, Iran
  • 2008 - NIH Director’s New Innovator Award, NIH Director’s Office, USA
  • 2004 - Champion for Diversity, University of California, San Francisco


  • Lunenfeld-Tanenbaum Research Institute

Twitter accounts

Look for Dr. Ramalho-Santos on Temerty Medicine Connect