Assistant Professor
Osama Abdin
Molecular Genetics
Location
SickKids - Peter Gilgan Centre for Research and Learning
Address
21.9707, 686 Bay Street, Toronto, Ontario Canada M5G 0A4
Research Interests
Cellular & Molecular Structure & Function, Computational and Systems Biology, Protein-protein, DNA-protein, and RNA-protein interactions, Structural biology, Technology development
Category
Cellular and Molecular Structure and Function, Computational and Systems Biology
My lab develops deep learning methods to model and design biomolecules, with a focus on protein and peptide-based agents. We primarily approach the development of these methods through the lens of dynamics. Fundamentally, biomolecular function is determined by the propensity of a biomolecule to assume different structural conformations, and the properties of these different conformations. The methods we develop integrate information about the dynamics of molecules to enable characterization of their function, and seek to modulate their dynamics to enable the design of new functions. Our long term goal is to enable the rapid engineering of proteins and peptides in silico with a high degree of control over their functional properties.