Peter Gilgan Centre for Research and Learning
686 Bay Street, 18-9708, Toronto, Ontario Canada M5G 0A4
Cancer, Cell biology
Research in Dr. Ran Kafri’s lab is primarily aimed at introducing the question of size uniformity into the subject of cell size. Two fundamental questions are:
- How does a common set of signals (including mTORC1) specify a different and distinct size for each of the different animal cell types?
- When considering cells of a given type, how are numerous individual cells in the tissue regulated to have the same exact size? Paradoxically, Dr. Kafri’s research findings on cell size have paved the road to a fundamentally new perspective on cancer prevention and cancer risk. Specifically, he examines whether a person's cancer risk derives from changes in the setpoint of mTORC1 homeostasis.