Ran Kafri

Research in Dr. Ran Kafri’s lab is primarily aimed at introducing the question of size uniformity into the subject of cell size. Two fundamental questions are:

1. How does a common set of signals (including mTORC1) specify a different and distinct size for each of the different animal cell types?
2. When considering cells of a given type, how are numerous individual cells in the tissue regulated to have the same exact size? Paradoxically, Dr. Kafri’s research findings on cell size have paved the road to a fundamentally new perspective on cancer prevention and cancer risk. Specifically, he examines whether a person's cancer risk derives from changes in the setpoint of mTORC1 homeostasis.