The Egan lab uses mouse models to study breast cancer. For example, we use gene targeting and chromosome engineering to design models for breast cancer which can be probed to define cooperative signalling networks that are involved in transformation and metastasis, and that can be targeted in the clinic. Transposon (Sleeping Beauty) and Apobec3 based approaches are used to study tumour evolution. Finally, our mouse models are used for the development of novel immune-based combination therapies.
- Signal Transduction And Cell Cycle Regulation (MGY425H1)
- Program in Cell Biology, the Hospital for Sick Children