Assistant Professor

Gregory Costain

Molecular Genetics


SickKids - Peter Gilgan Centre for Research and Learning
525 University Avenue, Suite 940, Toronto, Ontario Canada M5G 2L3
Research Interests
Genome analysis and sequencing, Neurodegeneration and neurodevelopment, Rare diseases, Zebrafish

The Costain lab is focused on understanding the causes and consequences of rare variation in the human genome. The team uses genome sequencing to discover new disease genes and genotype-phenotype associations, in a setting of an undiagnosed paediatric disease program. A related goal is to develop new methods for adjudicating the pathogenicity of rare genetic variants in humans.


  • Staff Physician, Division of Clinical & Metabolic Genetics, The Hospital for Sick Children
  • Scientist-Track Investigator, Genetics & Genome Biology, SickKids Research Institute
  • Assistant Professor, Department of Paediatrics, University of Toronto