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Assistant Professor

Khalid Al-Zahrani

Department of Molecular Genetics

PhD

Al-Zahrani profile pictures

khalid.alzahrani@utoronto.ca

Publications

Location
Terrence Donnelly Centre for Cellular & Biomolecular Research
Address
160 College Street, Room 308, Toronto, Ontario Canada M5S 3E1
Research Interests
Genetic Models of Disease & Development, Molecular Medicine & Human Genetics, Functional Genomics & Proteomics. , Cancer, Chromosome biology, CRISPR-Cas9 and genome engineering, Disease models, Functional genomics and systems biology, Mouse models, Signalling, Technology development
Category
Functional Genomics and Proteomics, Genetic Models of Development and Disease, Molecular Medicine and Human Genetics
Appointment Status
Primary

The Al-Zahrani Lab aims to develop and apply new high throughput in vivo functional genomics tools. We study how large-scale chromosomal alterations drive tumorigenesis and can be leveraged as a therapeutic vulnerability in cancer. While chromosomal instability is a hallmark of cancer, identifying which genes drive tumorigenesis is complicated by the fact that these unstable regions span hundreds-to-thousands of genes which can be lost, gained and/or re-arranged. To overcome this challenge, we perform multiplexed CRISPR screens in mouse models of disease to simultaneously assess the tumorigenic potential of all affected genes to identify cancer-specific drivers and vulnerabilities within the context of a native tumor microenvironment.

Awards
Cancer Research Society Next Generation Scientist